RABBIT PYROGEN TEST STUDY OF INFUSIBLE PLATELET MEMBRANE AS A PLATELET SUBSTITUTE FOR BLOOD TRANSFUSION
نویسندگان
چکیده
منابع مشابه
Infusible Platelet Membrane versus Conventional Platelet Concentrate: Benefits and Disadvantages
Blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. Many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. In this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...
متن کاملFlow Cytometric Measurement of CD41/CD61, CD42b Platelet Receptors and Platelet Factor 3 Activity in Lyophilized Infusible Platelet Membrane Preparation
Background: The short life time of human platelet units has led to a chronic shortage of fresh platelets in blood transfusion centers. Many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. Infusible platelet membrane (IPM) prepared from fresh or outdated human platelets have been developed as an altern...
متن کاملinfusible platelet membrane versus conventional platelet concentrate: benefits and disadvantages
blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. in this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...
متن کاملبررسی اثر سمیت زایی غشاء پلاکت قابل تزریق(IPM ) در موش: یک گزارش کوتاه
Background and Objective: Blood platelet units are generally stored in blood banks for 3–5 days, afterwards they are discarded. Prepared infusible platelet membrane (IPM) from fresh or outdated human platelets correct the prolonged bleeding times in thrombocytopenic animals such as rabbits. Abnormal Toxicity is an European Pharmacopoeia standard for assessment of biological products and th...
متن کاملBlood platelet kinetics and platelet transfusion.
The discovery of citrate anticoagulant in the 1920s and the development of plastic packs for blood collection in the 1960s laid the groundwork for platelet transfusion therapy on a scale not previously possible. A major limitation, however, was the finding that platelet concentrates prepared from blood anticoagulated with citrate were unsuitable for transfusion because of platelet clumping. We ...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2014
ISSN: 2250-1177
DOI: 10.22270/jddt.v4i6.993